Brief introduction of N-Fluorobenzenesulfonimide CAS 133745-75-2

Chemical name: N-Fluorobenzenesulfonimide 

CAS No.：133745-75-2

Synonyms:NFSI

Molecular Formula: C12H10FNO4S2

Molecuar Weight:315.34

EINECS: -

Properties of N-Fluorobenzenesulfonimide CAS 133745-75-2

NFSI is white solid appearance and a new, stable and mild fluorinating reagent. It can introduce fluorine atoms at the ortho position of the carbonyl group in organic molecules, and can perform monofluorination reactions on electron-rich aromatic compounds, enol silyl ethers, and olefin Chemicalbook alkoxide lithium salts. Current research hotspots are the Nazarov cyclization reaction to form a five-membered ring under the catalysis of iron or cobalt, and the asymmetric catalysis of enantioselective α-fluorination.

Specification of N-Fluorobenzenesulfonimide CAS 133745-75-2

Application of N-Fluorobenzenesulfonimide CAS 133745-75-2

1.Mainly used as a fluorinating agent, it can perform monofluorination reactions on electron-rich aromatic compounds, enol silyl ethers, enol lithium salts, etc.

2.A stable and mild fluorinating reagent, used for monofluorination of electron-rich aromatic compounds, enol silyl ethers, lithium enol salts, etc.; under the catalysis of chiral organic small molecules, NFSI can react with aldehydes, ketones, esters, etc. Electrophilic fluorination reaction of compounds with high enantioselectivity; under the catalysis of chiral metal complexes, NFSI can perform electrophilic fluorination reactions on substrates such as aldehydes, ketones, esters, etc., and the enantioselectivity of Chemicalbook is also high. ; 

3.As a fluorine reagent, it can be used for the addition reaction of double bonds; as a fluorine reagent, it can be used for the fluorination of aromatic compounds; used for the palladium-catalyzed enantioselective fluorination of tert-butoxycarbonyl lactone and lactam compounds; The electrophilic difluorination of dihalopyridine compounds under the action of butyllithium and the direct conversion of alcohols under the action of triphenylphosphine to bisbenzenesulfonimides

Packing, Delivery and Storage of N-Fluorobenzenesulfonimide CAS 133745-75-2

Package: 25kg /bag or fiber drum, or as per customer request.

Storage conditions: store in a cool and dry place.